5 Differences Between Ligaplex vs Glucosamine

Dealing with constant joint pain in your hands, knees, or shoulders is a terrible thing to go through. Most of the time, this is caused by osteoarthritis, the most common type of arthritis. Over a quarter of the population in the United States is affected by this kind of arthritis.

Anyone worried about joint pain or the wellness of their joints should go to the doctor for a complete diagnosis. There are, however, several supplements that could be able to maintain the joints in good condition.

Glucosamine and Ligaplex are two examples among many. It’s hard to say which of these two joint health supplements is better, ligaplex vs glucosamine.

Between ligaplex vs glucosamine, glucosamine works on knee joint degeneration pain, osteoarthritis, and rheumatoid arthritis. Ligaplex, on the contrary, gives better relief from connective tissue inflammation and strengthens the muscles and joints. Ligaplex shows fewer side effects than glucosamine.

And here is what we found when we looked into it in detail.

Ligaplex vs Glucosamine: Comparison Chart

TypesLigaplex I and Ligaplex IIGlucosamine sulfate and Glucosamine hydrochloride
Dosage500 milligrams 2 times a day500 milligrams 3 times a day
Scientific Research BackupNoYes
EffectSupport connective tissue, reducing inflammation, and strengthening the muscles, joints, and bones is the baneHelp slow knee joint degeneration and feel pain relief from osteoarthritis and rheumatoid arthritis, 

Ligaplex vs Glucosamine: Detail Differences

The quick chart won’t do any justice while comparing Ligaplex vs Glucosamine. There is more you need to focus on if you want to differentiate between these two bone and muscle tissue healing options.

Key Ingredients

Always check the label to be safe and see what’s in your food. To ensure you’re not consuming an unwanted addition, look up any ingredients listed that you’re not familiar with.


Among the constituents in Ligaplex I are Manganese B12, Vitamin B12, Cataplex E, Pea Vine Juice, Veal Bone, Buckwheat, and Ostrophin PMG. This dietary supplement is an excellent source of manganese and vitamin B12.

However, Ligaplex II combines essential compounds from Cyro-Yeast, Cardiotrophin PMG, Ostrophin PMG, Manganese B12, Carbamide, and Super-EFF. Plus, they are rich in vitamins A, B12, and manganese.

Differences Between Ligaplex 1 vs 2: At a Glance
Ligaplex ILigaplex II
Primary FocusAcute SupportChronic Support
TargetShort-term needsLong-term needs
Key IngredientsManganese, Vitamin C, Bovine Liver PMG™, Bovine Heart PMG™, Bovine Bone, Veal, Bone PMG™, Oat FlourManganese, Vitamin C, Bovine Liver PMG™, Bovine Heart PMG™, Bovine Bone, Veal Bone PMG™, Oat Flour

Bovine trachea, Bovine spleen, Carbamide, Soy Protein Isolate, Vitamin ABetaine Hydrochloride, Bovine Kidney, Calcium Lactate, Calcium Glycerophosphate, Inositol, Choline Bitartrate
Suggested UseSupport for connective tissue, joints, and muscles during periods of stress, injury, or inflammationSupport for connective tissue, joints, and muscles during long-term maintenance and repair

Standard Process Ligaplex II

  • Support the generation and maintenance of skeletal tissues
  • Maintain healthy fluid levels in your body
  • Comes with bovine heart PMG extract
  • Effective for Chronic Support



When sold as a supplement, glucosamine, or glucosamine chondroitin, is often derived from animal cartilage, shellfish shells, or lab-made compounds.

Various glucosamines are available, including sulfate, hydrochloride, and N-acetyl versions. It is necessary to use salt stabilizers to maintain the 74% purity of glucosamine sulfate. Glucosamine HCl is 99% pure and does not include the sulfate group.

Ligaplex II has many of the same elements as Glucosamine. Still, it also contains Boswellia Serrata, which relieves pain in the afflicted regions after strenuous activity.


Make sure you choose a supplement with the proper dosage for your needs.


To get the most out of both Ligaplex I and II, take two capsules twice a day with a meal. A doctor’s advice is always best regarding health issues, including allergies, sensitivities, or pre-existing diseases, before using Ligaplex.

When treating osteoarthritis, the median dosage of glucosamine was 500 mg three times a day in most trials.


It is recommended that the patient take 1,500 mg daily, either all at once or in two to three smaller doses, as a single tablet or powder for oral solution. Most adults take 1500 mg of glucosamine sulfate or glucosamine hydrochloride by mouth every day for up to 3 years.

Research and Clinical Trials

Let’s look at the scientific research and trials while comparing ligaplex vs glucosamine.


Ligaplex 1 gives the body the nutrients it needs to keep connective tissue healthy and reduce inflammation. Chiropractors often use this technique in the treatment of acute diseases.

The Ligaplex II, on the other hand, has a wide range of organic ingredients cultivated on the Standard Process farm. According to clinical research, bone health, and joint inflammation can improve with the help of these natural compounds.

Despite the scientifically proven advantages of Ligaplex’s components, no scientific support exists for its efficacy.

Glucosamine with Chondroitin With Turmeric & MSM

  • Provide Joint Discomfort Relief Occasionally
  • Helps In Inflammatory Response
  • Has Antioxidant Properties.
  • Works as a Supplement for Pain in the Back, Knees, and Hands


Studies have shown that glucosamine sulfate is much more effective in reducing pain than aspirin or ibuprofen for those who can’t use nonsteroidal anti-inflammatory medicines (NSAIDs).

You can try standard process glucosamine synergy as an effective alternative.

Glucosamine sulfate was also better than several other supplements for increasing physical function and curing chronic illnesses.

Check for the differences between Electrolytes and BCAA to strengthen your muscles.

Uses & Effectiveness

People with knee osteoarthritis can benefit from taking glucosamine sulfate orally. According to previous research, osteoarthritis-related knee joint deterioration could also be delayed. More research is needed to determine if glucosamine sulfate supplements help people with hip, spine, or hand osteoarthritis.


Rheumatoid arthritis discomfort could be reduced with the oral administration of glucosamine hydrochloride, according to preliminary studies.

On the other hand, researchers found no joint discomfort, swelling, or inflammation reduction. However, N-acetyl glucosamine’s effectiveness in treating osteoarthritis has yet to be shown clinically, necessitating more investigation.


Nutrition from Ligaplex 1 helps in the maintenance of connective tissue and the reduction of inflammation. Chiropractors often follow this process. Ligaplex II increases well-being by strengthening muscles, joints, and bones. Some of the ingredients in the product help repair worn-out bones and tissues within the body.

The vitamin C and manganese in Ligaplex help your body make collagen and help tissues heal and grow. Also supported by manganese is the amino acid proline, which is necessary for our collagen or cartilage to be formed.

Your connective tissue is stimulated by the PMG extracted from bovine and veal bone in Ligaplex II. Another reason why athletes appreciate Ligaplex I is that it includes buckwheat, a natural anti-inflammatory agent.

Also, to keep our joints healthy, Ligaplex II contains carbamide, which increases tissue fluid metabolism.

Safety and Side Effects

When directed, a small dose of glucosamine sulfate seems to have no side effects. Nausea, Heartburn, Diarrhea, and Constipation might occur when glucosamine sulfate is used orally. Drowsiness, skin sensitivities, and headache are less typical adverse effects that may occur.

Allergic reactions have been reported in those allergic to shellfish, which is thought to be the source of several glucosamine products. In addition, the supplement may exacerbate asthma symptoms.

Glucosamine has been reported to result in intraocular pressure. Consult your doctor before using glucosamine supplements if you have glaucoma.

The use of Ligaplex has not been associated with any adverse ligaplex i or ligaplex ii side effects. The negative impact of excessive manganese in the body, such as poor bone health or symptoms like Parkinson’s disease, may be dangerous since Ligalex employs Manganese (tremors).

It’s also important to check with your doctor before taking any supplement if you have any medical issues, such as allergies or sensitivities.

Ligaplex: What’s it about?

Ligaplex I and Ligaplex II are considered essential supplements for tissues and joints. This is because they offer the body the nutrition it needs to keep its muscles working correctly.

Do you need creatine in your overnight oats for better muscle strength?

Ligaplex I directly supports connective tissue and the natural healing process in joints. In contrast, Ligaplex II directly supports tissues and joints engaged in severe and repeated activities.

Calcium, Manganese, Vitamins A, C, D, B12, and other well-known joint-health-enhancing substances are all included in Ligaplex I and Ligaplex II.

Making a perfect blend of the active components in each product, essential nutrients are transported to cells where they can support cellular biochemical and physiological processes in tissue and joints.

A Little About Glucosamine

There are three different glucosamine supplements: glucosamine sulfate, glucosamine hydrochloride, and N-acetyl glucosamine.

As a building block for cartilage, tendons, ligaments, and synovial fluid, glucosamine is a vital human body component. Cartilage and the fluid that surrounds joints work together to have a cushioning effect. Taking glucosamine might strengthen the cartilage and fluid around the joints and help keep them from breaking down.

Osteoarthritis patients often turn to glucosamine sulfate and hydrochloride for relief. Glucosamine is usually prescribed for arthritis, rheumatic, and MS.

The Bottom Line

I think now you know what makes ligaplex vs glucosamine different.

However, Glucosamine is still a debatable supplement for osteoarthritis pain relief, and Ligaplex’s benefits have not been scientifically ‌effective. Then again, it hasn’t been shown that any of these supplements are bad for you.

Consider consulting your doctor or pharmacist before using any glucosamine supplements or the Ligaplex supplement if you have any medical conditions or medications. Also, have patience. It can take a few weeks for the full effect to show.

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